Accidental Blogger

A general interest blog

(Thanks to Ruchira for the idea and links)

‘Give us this day our daily meds’ has become the new grace all over the U.S. thanks to the agressive approach to sales and marketing of designer drugs by Big Pharma. While a huge amount of money has gone into finding cures for obscure conditions, the pharmaceutical industry’s investment is recouped a thousand-fold or more by simply persuading more people that they might suffer from the condition and therefore need drug XYZ to pre-emptively treat it.

Gone are the days of the snake-oil salesman climbing up on a crate to advertise his wares to small groups or quaint ads in papers with circulation and reach of a few thousand citizens.
Mothofdeath We now have celebrities asking us smilingly on TV whether we should be considering, now that we have turned 40/50/60, whether we can prevent osteoporosis by ingesting this or that pill. Or  the ‘radioactive moths of death’ flitting around to bestow the kiss of death-like sleep on people who ‘just can’t seem to sleep without waking through the night’.Or jolly little pastel balloons filled with water bouncing around London and Paris, with a burst balloon symbolizing ‘overactive bladder syndrome’. Or couples in tasteful embraces being interrupted during tender moments which are nevertheless easily postponed, due to the qualities of whatever ‘erectile dysfunction’ drug the ad is hawking.  Some of these ads come with a voice over rapping out the disclaimer in a monotone sure to lull the viewer into sleep (probably better than the sleep pill being hawked.)

(Moth of death photo from maxintosh’s flickr photostream)

This underlines the point that ‘Marketing, not research, is now the core of the drug industry‘ ( and almost all other consumer industries-as we have seen with books and authors recently.).

From the Washington Post review of a new book on the pharmaceutical industry "Our Daily Meds":

Take the selling of Zantac, an anti-ulcer drug that came on the market in 1983 and paved the way for the blockbuster drugs that followed. First, Glaxo priced its new drug above its competitor, Tagamet — a bold move, Melody Petersen writes in Our Daily Meds, that "like an underweight boxer trying to fool the prizefighter with his swagger . . . implied that Zantac was better." In reality, Zantac was a "me-too" drug, chemically almost identical to Tagamet and no more effective.

But it was the second half of Glaxo’s strategy that was truly dazzling. Rather than plowing the revenue from Zantac back into R&D, as was then customary in the drug business, the company decided to invest in marketing the daylights out of its drug. Glaxo funded studies intended to show Zantac’s superiority. It hired a battalion of sales reps, who flogged the drug relentlessly to doctors. Most brilliant of all, the company pioneered a ploy now used routinely in pharmaceutical marketing: It "condition branded" Zantac.

The net result was a sales bonanza for Glaxo as the demand for Zantac shot up. Other companies followed suit, inundating us in a flood of these ad campaigns.

In another example from this Houston Chronicle article:

One of the best examples is "osteopenia," a diagnosis that millions of women my age are given every year. Osteopenia is supposedly the precursor to osteoporosis, the gradual loss of bone that happens to most of us as we age. Advanced osteoporosis can make women vulnerable to hip fracture, a serious event when you’re old and frail because it often heralds a series of complications, such as pneumonia, that can ultimately lead to death. Millions of women are treated for osteoporosis with drugs that can slow bone loss, thus reducing the risk of hip fracture. Or so the logic goes.

The problem is, osteoporosis and osteopenia aren’t really diseases. Before the 1990s, doctors decided that you had osteoporosis if you were elderly and you broke a bone. When the pharmaceutical company Merck came up with its anti-bone-loss drug Fosamax, it wanted a broader market than just elderly fracture patients. The solution? The company helped fund a panel of medical experts to create diagnostic criteria for osteoporosis so that a diagnosis could be made before the patient actually broke a bone.

Voila — 30 percent of post-menopausal women suddenly had a disease that needed to be treated early in order to prevent a problem — hip fracture — that wouldn’t occur for many years, if ever.

OK, this does it. I’m going to get a bunch of doctors to declare compulsive blogging as ‘ Acute Blogging Syndrome’, come up with a designer drug to treat it and a marketing campaign to match (" Do you suffer from constant urges to ‘blog’, even at night… You could be suffering from ABS or acute blogging syndrome… Now you can treat it with one single pill ABStrex. Call your doctor and see if ABStrex is right for you… You should not take ABStrex if you have back aches, liver problems, heart problems, carpal tunnel or asthma. Certain medications may react adversely with ABStrex. You should not take ABStrex if you are pregnant or nursing or bottlefeeding…." .
Then ‘I’ll have made enough billions to pay for inviting all members of the Congress to all-expense paid parties on my private island, ferried aboard my private yacht to persuade them to nix a bill designed to curtail the ability of Big Pharma to limit the lawsuits which will be launched after finding out 5 years down the line that ABStrex leads to strokes and heart failure.

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5 responses to “Market of Maladies (Sujatha)”

  1. The most mystifying cure to have surfaced recently is for RLS (Restless Leg Syndrome). The syndrome is a real enough neurological condition recognized by the NIH and I suspect that drugs like Requip probably help. But what alarms me are the disclaimers that follow the commercials for the medications. When they first appeared, they were the garden variety list that you mention in your post. But a few months ago, I noticed an addition. Now the commercials also warn against watching out for “increased sexual and gambling urges.” So clearly, side effects on the central nervous system leading to addictive behavior have been recorded. Have they also studied what the long term risks like stroke or Parkinson’s Disease may be? Or are they unrelated in this case?
    The most annoying commercials for me are for drugs like Viagra and Cialis, where older couples are either seen simpering or doing “cool” things like riding motorcycles. One Viagra ad in which a garage band made up of a bunch of older guys sing “Viva Viagra” causes uncontrollable RLS like symptoms in me; I feel like kicking the TV.
    Isn’t there something terribly screwy about a health care system which picks up the prescription costs for Viagra and Cialis for aging men but not birth control aids for young women?

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  2. Sujatha

    Interestingly, even the Requip warning contains the following:
    “Requip Tablets may cause you to fall asleep or feel very sleepy during normal activities such as driving; or to faint or feel dizzy, nauseated, or sweaty when you stand up. Tell your doctor if you experience these problems or if you drink alcohol or are taking other medicines that make you drowsy. Also tell your doctor if you experience new or increased gambling, sexual, or other intense urges while taking Requip. Side effects include nausea, drowsiness, vomiting, and dizziness. Most patients were not bothered enough to stop taking Requip.”
    Of course there’s everything screwy about the health care system: it’s designed by men for men, which explains why ED takes precedence over birth control in the scheme of things. I don’t think even Hillarycare will get it out of that rut anytime soon. Maybe if all men could get pregnant, they would find a way to make sure that it is covered.

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  3. Sujatha

    The active ingredient in Requip is ropinirole, approved for treating Parkinson’s Disease in higher dosages and RLS at lower dosages.
    The problem I see with the use of these drugs to inhibit the symptoms is that no effort is made to address the root cause of the disease. These designer drugs add problems of their own in incomplete data regarding long-term effects, with no guarantee that the ailment will truly be ‘cured’, just temporary symptom relief and therefore a ‘golden goose’ for the drug company making the drug.

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  4. Sujatha, thanks for the “dope.”
    Of course there are several drugs which are used in different related conditions in differing doses. I guess RLS and Parkinson’s are related – both involving involuntary muscle spasms. Which is why I was wondering if prolonged use of ropinirole might eventually somehow make matters worse if it starts to be ineffective and make the convulsions worse – leading to more Parkinson’s like symptoms. But I may be overreacting.

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  5. Sujatha, I once wrote about the “golden goose” angle of drug marketing. That post was written in the early days of my blogging, perhaps before you had discovered A.B. Everyone, including the NIH and the Congress, knows about this mind set. But there is little they can do except to shame them. But big pharma is big business and shame is not a virtue they possess in abundance. The government cannot force them to manufacture “socially beneficial” products just as they cannot stop them from making “financially profitable” ones. The only time they can go after drug manufacturers is when they put out faulty or dangerous stuff. But even there, sometimes justice is not done if palms are crossed with appropriate dollar amounts.

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